Kynurenic acid protects against neurotoxicity and lethality of toxic extracts from contaminated atlantic coast mussels
Identifieur interne : 004A60 ( Main/Exploration ); précédent : 004A59; suivant : 004A61Kynurenic acid protects against neurotoxicity and lethality of toxic extracts from contaminated atlantic coast mussels
Auteurs : Carl Pinsky [Canada] ; Gary B. Giavim [Canada] ; Ranjan Bose [Canada]Source :
- Progress in Neuropsychopharmacology & Biological Psychiatry [ 0278-5846 ] ; 1989.
Abstract
1. An aqueous acidic extract from poisonous Atlantic coast mussels was injected i.p. into groups of Swiss-Webster mice at the LD84 value (=40 ml of extract/kg). Body-scratching, clonic convulsions and death were consistently observed in response to XTRT injection. These results are consistent with the presumed presence of the neuroexcitant amino acid, domoic acid, in the contaminated mussels.2. Kynurenic acid at 300 and 600 mg/kg i.p. protected powerfully and significantly against extract-induced neurotoxicity. Greatest protection was observed when the antidote was administered between 30 and 90 min after injection of the toxic extract.
Url:
DOI: 10.1016/0278-5846(89)90151-6
Affiliations:
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Giavim</name></author><author><name sortKey="Bose, Ranjan" sort="Bose, Ranjan" uniqKey="Bose R" first="Ranjan" last="Bose">Ranjan Bose</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8F349343019AAE9493B42E8361CE1BCC81168422</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1016/0278-5846(89)90151-6</idno><idno type="url">https://api-v5.istex.fr/document/8F349343019AAE9493B42E8361CE1BCC81168422/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001134</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001134</idno><idno type="wicri:Area/Istex/Curation">001134</idno><idno type="wicri:Area/Istex/Checkpoint">002160</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002160</idno><idno type="wicri:doubleKey">0278-5846:1989:Pinsky C:kynurenic:acid:protects</idno><idno type="wicri:Area/Main/Merge">005411</idno><idno type="wicri:Area/Main/Curation">004A60</idno><idno type="wicri:Area/Main/Exploration">004A60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Kynurenic acid protects against neurotoxicity and lethality of toxic extracts from contaminated atlantic coast mussels</title><author><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Giavim, Gary B" sort="Giavim, Gary B" uniqKey="Giavim G" first="Gary B." last="Giavim">Gary B. Giavim</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Bose, Ranjan" sort="Bose, Ranjan" uniqKey="Bose R" first="Ranjan" last="Bose">Ranjan Bose</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Progress in Neuropsychopharmacology & Biological Psychiatry</title><title level="j" type="abbrev">PNP</title><idno type="ISSN">0278-5846</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">3–4</biblScope><biblScope unit="page" from="595">595</biblScope><biblScope unit="page" to="598">598</biblScope></imprint><idno type="ISSN">0278-5846</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0278-5846</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. An aqueous acidic extract from poisonous Atlantic coast mussels was injected i.p. into groups of Swiss-Webster mice at the LD84 value (=40 ml of extract/kg). Body-scratching, clonic convulsions and death were consistently observed in response to XTRT injection. These results are consistent with the presumed presence of the neuroexcitant amino acid, domoic acid, in the contaminated mussels.2. Kynurenic acid at 300 and 600 mg/kg i.p. protected powerfully and significantly against extract-induced neurotoxicity. Greatest protection was observed when the antidote was administered between 30 and 90 min after injection of the toxic extract.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><region name="Manitoba"><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name></region><name sortKey="Bose, Ranjan" sort="Bose, Ranjan" uniqKey="Bose R" first="Ranjan" last="Bose">Ranjan Bose</name><name sortKey="Giavim, Gary B" sort="Giavim, Gary B" uniqKey="Giavim G" first="Gary B." last="Giavim">Gary B. Giavim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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